The effects of maitotoxin on phosphoinositides and calcium metabolism in a primary culture of aortic smooth muscle cells
Identifieur interne : 001856 ( Main/Exploration ); précédent : 001855; suivant : 001857The effects of maitotoxin on phosphoinositides and calcium metabolism in a primary culture of aortic smooth muscle cells
Auteurs : Philippe Berta [France] ; Sylvanin Phaneuf [France] ; Jean Derancourt [France] ; Jean Casanova [France] ; Monique Durand-Clement [France] ; Christian Le Peuch [France] ; Jacques Haiech [France] ; Jean-Claude Cavadore [France]Source :
- Toxicon [ 0041-0101 ] ; 1987.
Abstract
P. Berta, S. Phaneuf, J. Derancourt, J. Casanova, M. Durand-Clement, C. le Peuch, J. Haiech and J.-C. Cavadore. The effects of maitotoxin on phosphoinositides and calcium metabolism in a primary culture of aortic smooth muscle cells. Toxicon26, 133 – 141, 1988. — Maitotoxin, a potent marine toxin isolated from toxic tropical dinoflagellates and poisonous fishes induces contraction of different smooth muscle preparations. Actions of maitotoxin on phosphoinositides and calcium metabolism were studied using a primary culture of aortic smooth muscle cells. Maitotoxin induced a very large increase of cytosolic calcium concentration as evaluated by fura-2 acetoxymethyl ester fluorescence. This increase was concomitant with stimulation of inositol-phosphate accumulation and loss of viability of aortic smooth muscle cells. These responses to maitotoxin were abolished in Ca2+-free medium, and were mimicked by saponin. Calcium ionophores or K+ depolarisation did not induce inositol-phosphate formation. These results suggest that maitotoxin acts by altering smooth muscle cells permeability allowing a sustained calcium influx which is able to activate inositol-phosphate formation and which is lethal for the cells.
Url:
DOI: 10.1016/0041-0101(88)90165-1
Affiliations:
- France
- Languedoc-Roussillon, Occitanie (région administrative), Provence-Alpes-Côte d'Azur
- Montpellier, Villefranche/Mer
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Le document en format XML
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<front><div type="abstract" xml:lang="en">P. Berta, S. Phaneuf, J. Derancourt, J. Casanova, M. Durand-Clement, C. le Peuch, J. Haiech and J.-C. Cavadore. The effects of maitotoxin on phosphoinositides and calcium metabolism in a primary culture of aortic smooth muscle cells. Toxicon26, 133 – 141, 1988. — Maitotoxin, a potent marine toxin isolated from toxic tropical dinoflagellates and poisonous fishes induces contraction of different smooth muscle preparations. Actions of maitotoxin on phosphoinositides and calcium metabolism were studied using a primary culture of aortic smooth muscle cells. Maitotoxin induced a very large increase of cytosolic calcium concentration as evaluated by fura-2 acetoxymethyl ester fluorescence. This increase was concomitant with stimulation of inositol-phosphate accumulation and loss of viability of aortic smooth muscle cells. These responses to maitotoxin were abolished in Ca2+-free medium, and were mimicked by saponin. Calcium ionophores or K+ depolarisation did not induce inositol-phosphate formation. These results suggest that maitotoxin acts by altering smooth muscle cells permeability allowing a sustained calcium influx which is able to activate inositol-phosphate formation and which is lethal for the cells.</div>
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